San Luciano Lab At UCSF
Our mission is to advance personalized therapeutic approaches for individuals living with movement disorders. By combining cutting-edge clinical research and innovative neuromodulation techniques, we aim to transform the lives of those affected by these challenging conditions.
Our work is focused on understanding and targeting the brain systems that regulate movement. We are leading a groundbreaking clinical trial on cerebellar neuromodulation for dystonia associated with cerebral palsy, exploring new frontiers in deep brain stimulation. In addition, we conduct clinical trials aimed at developing novel treatments for genetic forms of Parkinson’s disease. Through these efforts, we hope to uncover fundamental insights into the neural mechanisms underlying movement, paving the way for highly individualized and effective therapies.
Cerebellar DBS for Movement Disorders in Children and Young Adults with Cerebral Palsy
Using advanced brain and movement recordings, we aim to find brain signals linked to dystonic cerebral palsy and understand if this new treatment can improve daily life.
Cerebellar-Cortical Networks in Patients with Dyskinetic Cerebral Palsy
Leveraging cerebellar deep brain stimulation and EEG to reveal neural dynamics underlying motor and non-motor functions and guide next-generation neuromodulation therapies.
LRRK2-targeting Therapies for Parkinson’s Disease
Evaluating BIIB122's safety, biomarker engagement, and potential to slow disease progression in both idiopathic and genetic forms of Parkinson’s.
When, Where and How to Stimulate the Cerebellum (Adaptive DBS targeting Dentate Nucleus to Treat Ataxia)
Utilizing adaptive deep brain stimulation of the dentate nucleus in SCA6 to define cerebellar biomarkers and develop closed-loop strategies that restore motor function, in collaboration with the University of Florida.